Server IP cope with resolved: Yes Http reaction code: 200 Response time: 0.27 sec. But not 150K. He's founded 7 companies, 2 with billion dollar valuations. One Silicon Valley entrepreneur thought he could beat the odds. That study was featured on 60 Minutes. The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). If you have trouble getting a prescription, perhaps you have OCD? In that same IEEE Spectrum story about his then-new startup, Propel Software, he said he felt successful, but not famous. Medicine has been transformed to doing whatever the NIH/FDA says, regardless of how many lives will be lost. [NIH] doesnt want any of these treatments. Entrepreneur Steve Kirsch who holds an early patent for the optical mouse decided to get involved in treating Covid. Zero. Steve Kirsch is a high-tech serial entrepreneur based in Silicon Valley. iRobot said it had consent to collect this kind of data from inside homesbut participants say otherwise. If you start later, doctors use higher dosages and compliance becomes a bigger problem. It does not matter how many lives will be saved. The medical community doesnt care about saving lives. Its actually much harder to parse out a signal than if youre treating diabetes or cancer., In addition to the issues with fluvoxamine, advisors grew increasingly uncomfortable with Kirschs posts about ivermectin, which he has repeatedly claimed in blog posts and appearances in alternative media can be used together with fluvoxamine to prevent 100% of covid-19 deaths. My crime? The medical community doesnt care about saving lives. Timing is everything with respect to outcomes. It was recommended back in January 2021 by a key opinion leader (KOL) panel to be used, but it took a year for the KOL meeting notes to be published because they were rejected by 10 journals. Items included in the Television News search service. The trials that were abandoned for futility werent getting events because the patients were given standard of care meds. And not zero., Kirsch immediately forwarded the exchange to me and, I suspect, other journalists. The External Medicine Podcast - Fluvoxamine as a potential treatment for COVID-19: An Interview with Steve Kirsch. His efforts became more focused on medical research when, in 2007, he was diagnosed with a rare blood cancer. His appearance on an episode of anti-covid-vaccine, pro-ivermectin pundit Bret Weinsteins DarkHorse podcast, alongside Robert Malone, a prominent source of vaccine misinformation, introduced Kirsch to followers of the intellectual dark web, who have since embraced him as a fellow truth-teller. Fluvoxamine is a very safe drug on market for 37 years, tens of millions of people have taken it, no record in scientific literature of anyone dying on overdose, and according to doctors that know the drug the best, about as dangerous as taking a Tylenol. The Lancet paper showed that if you were treated early enough and took the drug as prescribed (it only works if you take it), it was shown to reduce your chance of death by 12X making it far more effective than any other drug for COVID. A very short op-ed arguing for using fluvoxamine against COVID. In 2016, it was the 135th most-prescribed medication in the United States, with more than 4 million prescriptions. Steve Kirsch Nov 5, 2021 145 92 Here are the key things you should know about fluvoxamine for COVID: It works. I have all of these on hand and I load up on vitamin D3 every day. In it, he claimed mRNA vaccines kill one in 5,000 recipients and dramatically increase the rate of miscarriages. He considers himself an expert in something that he doesnt have training or experience in, and hes not following scientific methods to assess data.. The paramedics will think you are on drugs. And, according to three members of CETF's scientific advisory board, he put pressure on them to promote fluvoxamine for clinical use without conclusive data that it worked for . This is a more comprehensive look at the key evidence supporting fluvoxamine: Hear from the doctors who did the studies directly as well as the Dean of Medicine at Emory University: List of the best evidence-based COVID treatment options. The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. See this. ICER: If the drug is started right after symptoms, weve seen 100% prevention in hospitalization. Over the summer, the conflict reached his most recent startup, M10. After two weeks (since it was a tight knit community, everyone could see what was happening to the two groups), every track worker who got sick with COVID, demanded the drug. Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. An approach that promised to democratize design may have done the opposite. It is not unusual to be wary of developing science, or wrong to be skeptical of pharmaceutical companies. I believe they made the right decision and we should be rushing to follow their advice. Think about it Molnupiravir has a 50% risk reduction whereas fluvxoamine is over 90%. NIH doesnt want you to get the drug since it would compete with Molnupiravir, so fluvoxamine will never make the NIH guidelines. We should be making decisions now based on the evidence on the table today. Fluvoxamine (Luvox) is a Selective Serotonin Receptor Inhibitor (SSRI) that is clinically indicated for OCD in children, and can be used off label for depression. They immediately ruled out the vaccine, because the vaccine is, quote, safe.. Dr. Seftel's paper has been accepted for publication and will appear in OFID in early February. As of November 13, fluvoxamine has been proven to work in every trial that has published results, including outpatient and inpatient studies. Quick Summary . Fluvoxamine for COVID-19 summary Steve Kirsch Executive Director COVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008 Google Docs This is a more comprehensive look at the key evidence supporting fluvoxamine: Fluvoxamine for COVID-19 If you are experiencing any odd adverse reactions, youll need to consult with your doctor ASAP. He has been a medical philanthropist for more than 20 years. Since then, he has continued to promote fluvoxamine, along with ivermectin and hydroxychloroquine. The next major effect is that that fluvoxamine activates the sigma-1 receptor. Fluvoxamine has a 40 year safety track record. At the dosing for COVID (50mg BID x 14 days), there is a 1% chance of mild-nausea and because the dose is so low and the time it is taken is so short, and there are no psychotropic effects (which require more than 3 weeks of use; the psychotropic effects non-existent if you don't have depression or an anxiety disorder in the first place). A very short op-ed arguing for using fluvoxamine against COVID. A very short op-ed arguing for using fluvoxamine against COVID. The effect size is huge if the drug is given early right after symptoms start. Medicine today isnt about saving your life. But fear of trying something new prevents any doctor from giving this drug a try. That was a big mistake because the original paper contained text related to earlier studies and the editors chopped it out. So probability of successful Phase 3 can be estimated to be over 99.99% since there are tens of thousands of phase 3 studies. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. They knew in advance it was coming and on the day the paper was published they ignored it entirely. There is absolutely no evidence that either one of these claims is true, as Morris has carefully documented. Please read and agree to the disclaimer before watching this video.. Steve Kirsch On COVID Early Treatment and CensorshipSteve Kirsch is an entrepreneur and . He was recently featured on 60 Minutes, . Talking to Kirsch is an exhausting experience. Get your prescription in advance of getting COVID. . Steve angrily decried this development as more evidence of FDA corruption. Drug researchers at Washington University in St. Louis reached out to Kirsch looking for $67,000 to finish a very smallbut placebo-controlledtrial. Steve Kirsch is an inventor of the optimal mouse, a Silicon Valley millionaire, and an MIT alum (Class of '80). The drug was widely prescribed as a covid treatment for much of 2020, based on anecdotes and flawed studies. So when a group of scientists applied for an EUA for fluvoxamine, what did the FDA do? That was a lie. It has enrolled only 130 people in the first month and is enrolling only 70 per week now. But how many did it help? The ongoing battle between social-media companies and covid-19 misinformation pushersincluding US president Donald Trumpstepped up again this week thanks to a new viral video. Although there is evidence that fluvoxamine can prevent clinical worsening and the need for hospitalizations in outpatients with early covid-19, I have seen no good evidence that fluvoxamine is useful as a substitute for the vaccines, co-investigator Angela Reiersen wrote to me. If you ask your doctor for any evidence that fluvoxamine doesnt work or is harmful (like a DB-RCT which is the only thing they trust), they will show you nothing. All this was known back in January 2021 when a key opinion leader panel of experts from NIH, CDC, FDA, academia, and journal editors voted by over 2:1 to recommend that fluvoxamine be recommended to physicians to discuss with patients. Hes a genuinely good guy. Immediately after the results of the first fluvoxamine trial were releasedbut before they were published in a peer-reviewed journalhe wrote a post on Medium.com called The Fast, Easy, Safe, Simple, Low-Cost Solution to COVID That Works 100% of the Time That Nobody Wants to Talk About.. The other doctors aren't using it either because they don't know about it or fear doing anything not approved by the CDC for treating COVID. This is quite stunning because the PK of the drug done at the Gates Foundation shows it only reaches 50% of the final concentration after 3 days. upcoming events, and more. reach out to us at . The track management was so impressed, they asked for prescriptions. The data is there in plain sight for anyone to see today. The NIH never did a risk benefit analysis of this drug. In other cases, stop cold turkey. So check the side-effects list to be familiar with which side-effects are associated with which drug so if you have a side-effect, youll know which drug to reduce or eliminate. I fixed the link to the fluvoxamine article. Now they turn to Rust. Here is what, e) which concluded: Under a variety of assumptions, fluvoxamine shows a high probability of preventing hospitalization in outpatients with COVID-19., For more about fluvoxamine (and other SSRIs that work), see, fluvoxamine completed a Phase 3 study showing it works that was published in the Lancet Global Health, NIH basically dismissed the fluvoxamine study as I predicted they would, few people werent afraid of expressing their displeasure, the highly acclaimed Bangladesh mask study showed, Johns Hopkins has incorporated fluvoxamine in their treatment guidelines, Ontario has become the first province to list fluvoxamine as a treatment doctors can consider for patients. . Sage Hana. FDA official fluvoxamine rejection. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. The. It could do nothing. 22, 2021, 9:00 a.m. Steve Kirsch , a former tech entrepreneur who earned a fortune worth up to $300 million, has been showcased on TrialSite a few times for his activity supporting the clinical development of repurposed drugs for COVID-19 treatments. Hes probably the closest thing Kirsch has to a nemesis, regularly disputing his assertions in blog posts and private email exchanges with Kirsch and his friends. I was just getting tired, he said, before asking to speak off the record. Steve Kirsch is looking for an explanation for 171,000 excess deaths. Their willingness to lie did. Nobody in the medical community is speaking out about how hypocritical the medical community is for ignoring the positive Phase 3 trial results and instead following whatever the NIH or FDA says. Hes also recently increased the number of Americans he claim have been killed by the vaccine from 25,0000, to 150,000, or even as many as 250,000 Americans. The post read: "I will be featured on 60 Minutes this Sunday talking about fluvoxamine as an effective treatment for COVID-19 to prevent hospitalization and death. Its board told him that if he wanted to remain part of the company he would have to stop making public anti-vaccine statements. Over the next few years, millions of unvaccinated people are going to get covid; its vital to try to mitigate their suffering, as well as lessen pressure on the health care system. We should not wait for the Phase 3 RCT. Government agencies are ignoring the science. This alone will give roughly a 50% effect size and explains why all of the the SSRIs are effective including those that do not activate the Sigma1 receptor (e.g., Paroxetine). 1:49 He wrote on his personal website that hed been advised that being associated with the drug would immediately trash my credibility.. That work has yielded one promising candidate, the antidepressant fluvoxamine; other CETF-funded efforts have been less successful. I didnt intend to spend a lot of time on Steve in particular, but that video was so influential.. It could do nothing. The study was also featured on 60 Minutes. So it was both obvious and convincing the difference between the groups to the workers and the track management. That was a lie. David Boulware, a researcher at the University of Minnesota, received $125,000 to test the drug against covid. You cannot get any better than that. So take the lowest likely effect size * 60% success rate and you are looking at an expected 45% reduction in death which is clearly better than a 0% reduction. Dosage there is 30mg once a day. This is the #1 ranked best answer to "COVID treatment" on Quora: Presentation on how fear of trying something new is what keeps us shutdown and leads to unnecessary loss of life: The Lenze fluvoxamine RCT that was published in JAMA on November 12, 2020 showed a 100% success rate in preventing hospitalization. In the studies and the anecdotes I am aware of, everyone reversed symptoms within days of getting the drug. Medicine isnt about saving lives anymore. Online Status. Last Checked: 03/03/2023. Why the FDA should grant an EUA for fluvoxamine immediately, a brilliant op-ed in the Wall Street Journal, "Too much caution is killing COVID patients. Please, As of November 13, fluvoxamine has been proven to work in every trial that has published results, including, studies. Their willingness to lie did. There is no evidence fluvoxamine is harmful and led to a worse outcome. This post was written to memorialize the corruption. It was approved by the FDA in 1994 and has been used in millions of patients worldwide. Here are the key things you should know about fluvoxamine for COVID: It works. Thats pretty typical, but your mileage may vary. Design thinking was supposed to fix the world. As trial results rolled in, that mismatch began to put a strain on Kirschs relationship with the funds advisory board. Kirsch, despite having direct access to the actual trial runner, eventually became convinced a correct interpretation of the data would show that hydroxychloroquine worked. The evidence is solid. They knew in advance it was coming and on the day the paper was published they ignored it entirely. The premise made sense: Most experts were predicting vaccines would take years, while finding helpful drugs with known safety profiles could shortcut the approval process. One of the first CETF grants was to investigate the antimalarial hydroxychloroquine. It was so bad you couldnt even see the babys body through all the blood, Kirsch said. The differences are obvious to untrained eyes. Doctors wait for government permission (EUA or added to the NIH guidelines) before using a drug. Decreasing the dosage or stopping the medication will mitigate symptoms within hours. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital security (OneID), or e-commerce (Propel Software). Both of them encouraged anyone reading this article to get vaccinated. Dosing. He is very smart, and he knows that he is very smart, and hesometimes he behaves like he thinks hes the smartest guy in the room, whether he is or isnt, he told me. Medicine today isnt about saving your life. I fully expected both organizations to do absolutely nothing. Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI), a class of anti-depressants, mostly prescribed for people suffering from an obsessive-compulsive disorder. Why fluvoxamine isnt used. Hes very convincing. In 2013, Johnson & Johnson paid $2.2 billion for its own kickback and fraud scandal, including a specific $400 million fine for its subsidiary Janssen, which manufactures the covid vaccine. . How can the FDA say a drug which meets the gold standard of evidence has insufficient evidence? Fluvoxamine has a 40 year safety track record. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. It's hard to ignore this lecture in explaining why the drug is so effective. The results would, eventually, set Kirsch on a collision course with the scientific establishment. Compulsive fiddling with your mask? Doctors are afraid that even with a 37-year safety record of this drug, that something will go terribly wrong and they will be blamed. Quick Summary . Most recent articles first. You see this with people who have a lot of money, who think that reflects their intelligence, Richman told me. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. 33. ALWAYS check with your doctor and report any medications you are taking before or plan to take after you start taking fluvoxamine. Fluvoxamine is also an 90,000 people don't have to die in the next 3 weeks. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. His latest startup, M10, is a spin-off of a spin-off that sells a blockchain for banks. They left their recommendation of fluvoxamine at NEUTRAL. Its whether Merck can make a killing that matters. Several former members told me he began relentlessly pressuring them to promote the drug in media stories, often during exhausting, circuitous conversations. But even she was drained by Kirschs constant attempts to override the data. They rejected the drug for insufficient evidence just like they always do for ivermectin. The NIH wrote a bullshit rejection because the FDA told them not to approve it. . Jeffrey Morris, director of biostatistics at the University of Pennsylvania Perelman School of Medicine, has made debunking Kirschs claims something of a hobby. Yeah, its possible, he told mehe also says that he has regularly seen Kirsch manipulate evidence so that it seems to support claims that are, in reality, baseless. So instead of this paper being treated as confirming an earlier hypothesis, it was treated as generating a novel hypothesis. All the researchers are convinced the drug works. Added to FLCCC protocols and Fareed-Tyson protocol among others. On January 22, 2021, thirty key opinion leaders (KOL) from NIH, CDC, and leading academic institutions met to review the evidence for using fluvoxamine for treating COVID. He pushes fluvoxamine, an anti-depression drug which despite doing very well in covid treatment studies has been strangely neglected. One user reported dilated pupils and increased heart rate (which could be nerves about the dilated pupils). Read More fluvoxamine The Fluvoxamine FAQ On his blog, Covid-19 Data Science, he has extensivelyand mercilesslyunpacked Kirschs evidence for the vaccine death claims. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. And he wont talk to you either if you ask nosy questions like Cliff, my risk benefit analysis shows you should be rushing to recommend this drug. Note that some of these articles are inaccurate. This should be top news, but the press is ignoring this and attempt to write stories about it are killed by the editors. 12:45 AM . If you ask your doctor for any evidence that fluvoxamine doesnt work or is harmful (like a DB-RCT which is the only thing they trust), they will show you nothing. So much for evidence-based medicine. The board members I spoke to say they refused to publicly promote any drugs for off-label use and tried to explain to Kirsch that its incredibly common for exciting results from small trials to disappear in larger ones. Doctors wait for government permission (EUA or added to the NIH guidelines) before using a drug. This is the gold standard of evidence based medicine. That way you can start immediately. Always be self aware when using fluvoxamine. You will be wired for 24 hours if you dont heed my advice. The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! . @stkirsch. There were no studies reported out so far where fluvoxamine made things worse or neutral. Steve Kirsch is a Silicon Valley philanthropist. As a health care journalist, I started off firmly in the wait-and-see camp on mRNA vaccines. Have the drug on hand. Still, in the moment, his question threw me, and I stuttered. But they dont want their names used. Every year, we pick the 10 technologies that matter the most right now. Kirsch IDeacon BJHuedo-Medina TBScoboria AMoore TJJohnson BT Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. To protect M10 from my COVID-19 vaccination opinions, I will no longer post about my vaccination concerns here.. Skirsch.io site visitors volume is 1,957 unique day-to-day guests and their 3,914 pageviews. Also, this drug is only prescribed by psychiatrists so most doctors have no experience whatsoever with the drug. Steve Kirsch is baffled. I mean, he really, truly has a heart of gold, Char told me. Thanks for working tirelessly to help others. I think we did rigorous reviews of proposals for research.. But the whole process has gone too slowly for Kirsch. He felt like he in good conscience had to speak out about covid, and so he made the decision to separate himself from M10, says Char, who has known Kirsch since the 1980s. We have a bounty of vaccines and more on the way, but drugs that treat the disease are vital too if we want to keep people alive and bring the pandemic under control. Saving the world has been a theme of Kirschs life for years. After I ended the Zoom meeting, Satterfield called me to apologize for cutting us off. These huge businesses do often prioritize profits over human health: in 2009, Pfizer paid a $2.3 billion settlement over kickbacks and fraudulent marketing, including a $1.3 billion felony fine. What's even worse is that a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die. Vaccine waitlist Dr. B collected data from millions. The incident, he added, was completely in keeping with his personality.. So much for evidence-based medicine. Ive used it personally at 50mg twice a day and experience no adverse events at all.