For this reason, it is important to stay up to date with boosters. The current report aims to present a rare case of false-positive human immunodeficiency virus (HIV) in a COVID-19 patient. (A-B) show multiple peripheral alveolar consolidations in both lower lobes and left upper lobe of the lung (red arrowhead), compatible with a viral pneumonia. The https:// ensures that you are connecting to the Charpentier C, Ichou H, Damond F, Bouvet E, Chaix ML, Ferr V, Delaugerre C, Mahjoub N, Larrouy L, Le Hingrat Q, Visseaux B, Mackiewicz V, Descamps D, Fidouh-Houhou N. J Clin Virol. government site. These viruses possess They are also relapsing conditions, in which periods of abstinence (not using substances) can be followed by a return to use. 2023, March 30. 2023 Healthline Media UK Ltd, Brighton, UK. 2016;23(7):540545. The U.S. Food and Drug Administration said on Tuesday it is alerting clinical laboratory staff and healthcare providers that false positive results can occur with COVID-19 antigen tests. All reactive (potentially positive) results are checked with extra confirmatory tests. Laboratories should expect some false positive results to occur even when very accurate tests are used for screening large populations with a low prevalence of Additionally, the CDC recommends individuals at higher risk get tested at least once a year. When the result is borderline, experienced staff give more consistently accurate results. Forty-five percent of COVID-19 patients tested positive for HSV IgM with Liaison. Underlying conditions such as diabetes and hypertension are common among PLHIV. 2023 Healthline Media UK Ltd, Brighton, UK. 5 allows us to reach millions of people globally with accurate and reliable resources about HIV prevention and treatment. Can diet help improve depression symptoms? Case report: A 32-year-old female complaining from thyroid problems referred for thyroid operation. -, Baram A., Kakamad F.H., Abdullah H.M., Mohammed-Saeed D.H., Hussein D.A., Mohammed S.H., et al. We hope that both clinicians and patients understand that buprenorphine is a safe and effective option.. Advances in Immunoassay Technology. There are several reasons why a person may test positive after getting vaccinated. If someone has symptoms, they should have a test immediately. They also bolster support for expanding access to buprenorphine. Iriemenam NC, Ige FA, Greby SM, Okunoye OO, Uwandu M, Aniedobe M, Nwaiwu SO, Mba N, Okoli M, William NE, Ehoche A, Mpamugo A, Mitchell A, Stafford KA, Thomas AN, Olaleye T, Akinmulero OO, Agala NP, Abubakar AG, Owens A, Gwyn SE, Rogier E, Udhayakumar V, Steinhardt LC, Martin DL, Okoye MI, Audu R. J Clin Virol Plus. And in its ASX statement CSL said people in the 216-person trial were fully informed of this possibility. The results may surprise you. Accessibility In the same way, those who suspect possible exposure to HIV should speak with their healthcare providers about taking post-exposure prophylaxis. Annals of Medicine and Surgery. Learn more here. If your behaviour is unlikely to put you at risk for HIV and you live in a community in which HIV infection is quite uncommon, and you have received a reactive result with a single test, this result should be interpreted with caution. T3 Instead, these vaccines work by training the immune system to detect and fight the virus. 8600 Rockville Pike Early Career Research Leader, Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University. 4562. Survived COVID-19 patient presented with death on arrival: a case report. See here for a complete list of exchanges and delays. h Clin Vaccine Immunol: CVI. This would have meant unnecessary anxiety while people sought further clarification about their HIV status. And this should reinforce the publics confidence in Australias COVID vaccination program, due to start from March 2021. WebThe current report aims to present a rare case of false-positive human immunodeficiency virus (HIV) in a COVID-19 patient. As well as the Oxford/AstraZeneca vaccine, existing arrangements are in place to supply Australians with the Pfizer/BioNTech and Novavax vaccines, should they prove safe and effective. Any donation you make helps us continue our work towards a world where HIV is no longer a threat to health or happiness. Before HHS Vulnerability Disclosure, Help We know that less than 23% of people with opioid use disorder are getting treated for it, and we only have a few medications for opioid use disorder that have been found to be very effective for opioid withdrawal to date. Receptive anal sex, or receiving the penis into the anus, also increases transmission risk. Testing too early can produce inaccurate results. There are several reasons why this might happen: No, the vaccine cannot cause a SARS-CoV-2 infection. The CDC states that HIV tests have 99.6% specificity. WebForty-five percent of COVID-19 patients tested positive for HSV IgM with Liaison. When a person does not have a medical condition but is diagnosed as having it. Centers for Disease Control and Prevention. Performance of nucleocapsid and spike-based SARS-CoV-2 serologic assays. Schiettecatte J, Anckaert E, Smitz J. False positive; Herpes simplex IgM; Immunoassay; Interference; Polyvinylpyrrolidone; SARS-CoV-2. Trials. If a person tests during this time, they will likely receive a negative result. Sensitivity is an indication of test performance when testing people who do have HIV, whereas specificity reflects test performance in relation to people who do not have HIV. A small portion of Corona Virus disease-2019 (COVID-19) cases associated with co-infections, however occasionally they turn out to be false positive due to possible cross-reactivities. There is no possibility that COVID-19 booster vaccines can lead to HIV or AIDS, according to experts. Annals of Medicine and Surgery. How did the University of Queensland/CSL vaccine fail due to 'false positive' HIV tests? Read more: 2004;25(2):105120. Most testing sites use HIV antibody tests, called ELISA tests, for rapid screening of HIV. The COVID-19 vaccine cannot stop a person getting the virus, but the symptoms will be less severe. We are in an overdose crisis, and we need to deploy every tool we have to help address it, said Nora D. Volkow, M.D., director of NIDA. 4 key questions answered, From adenoviruses to RNA: the pros and cons of different COVID vaccine technologies, Facilities Development and Maintenance Coordinator, Alumni and Community Engagement Coordinator. An Australian COVID-19 vaccine that had shown promising results in early trials is being abandoned after researchers found that the shot caused false-positive 2023, http://nida.nih.gov/news-events/news-releases/2023/03/Buprenorphine-initiation-in-ER-found-safe-and-effective-for-individuals-with-OUD-using-fentanyl, NIDA. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. A prospective, randomized, single-blinded, crossover trial to investigate the effect of a wearable device in addition to a daily symptom diary for the Remote Early Detection of SARS-CoV-2 infections (COVID-RED): a structured summary of a study protocol for a randomized controlled trial. This work was supported by NIDAs Clinical Trials Network (UG1DA015831-18S7), a nationwide consortium aimed at testing drug use interventions and delivering evidence-based therapies to diverse patient populations. By itself, this is harmless and cannot cause an HIV infection or AIDS. FOIA The emergency department is an important touchpoint for providing life-saving medication and resources for people at risk for overdose, said Rebecca G. Baker, Ph.D., director of the NIH HEAL Initiative. Thats why its still important to pursue a broad portfolio of vaccine approaches and technologies. The findings, which appeared today in JAMA Network Open, are strong evidence that buprenorphine, a medication approved by the U.S. Food and Drug Administration to treat opioid use disorder, can be safely started in the emergency department without triggering withdrawal, even for people who use stronger opioids. COVID-19 misinformation runs wild on social media. Federal government websites often end in .gov or .mil. The CDC measures a specific behaviors likelihood to transmit HIV for every 10,000 exposures. The https:// ensures that you are connecting to the We need to meet people where they are amid an increasingly deadly overdose crisis.. International Journal of Surgery Case Reports. Declaration of competing interest The authors declare that they have no conflict of interest. Bookshelf Rapid tests are point-of-care tests that can provide results in minutes. Company limited by guarantee. Vaccines, including Covid-19 vaccines cannot cause AIDS / HIV or make us more susceptible to contracting this or any other virus.. This sequence of confirmatory tests is carefully planned to prevent inaccurate results from being given. It is important to note that the vaccine does not cause an infection. Second, the test may report a false positive. Experts developed several effective vaccines that have been instrumental in controlling the pandemic. reading the test before or after the specified time. iP(G P`P*]W d`b$!II=`if A person at risk of contracting HIV should get screened for HIV and other STIs. I certainly dont think its the end of this technology. The Oxford/AstraZeneca vaccine is the first to publish peer-reviewed efficacy results. In 2019, the Centers for Disease Control and Prevention (CDC) estimated that 1.2 million people in the United States have HIV, and close to 160,000 are unaware they have the condition. How well a vaccine protects someone depends on their: Because vaccines cannot guarantee complete protection against COVID-19, people should still wear masks and adhere to social distancing and other guidelines. The most common causes of an incorrect HIV test result include the timing of testing, type of HIV test used, other health conditions, technical issues at the testing site, or a faulty HIV test. March 30, 2023, NIDA Press Office NIDA. If you tested in a healthcare facility, the staff there should make sure you have the necessary follow-up tests. This means that a patient may be told that they have COVID-19, but they actually do not. A person tested for HIV may get a false-positive result due to errors in home tests, the presence of other health conditions, and facility or provider-based issues. Rapid Covid tests give many false negatives, but that might mean you're not contagious. If the result is reactive, this indicates that the test has reacted to something in your blood and needs to be investigated further. doi: 10.7759/cureus.34096. Last medically reviewed on November 23, 2021, A false-positive HIV test occurs when a test incorrectly indicates that a person has contracted the virus. Getting a nonreactive result from an HIV test does not necessarily mean a person has tested negative. hjB1_evus~WRJP7}'u&2gFAz 4:},f|,)4 8UJ6&r@$qnCr[h[~JH_o#:%fMkIc5wm(wT=o\?^~c_2pOzw0{'j8v_y' T endstream endobj 276 0 obj <>stream Recent legislation removed barriers to access, including the elimination of the X-Waiver in December 2022, and policy efforts have been initiated that maintain COVID-19 era-initiated flexibilities related to prescribing buprenorphine via telehealth evaluations. For more information about NIH and its programs, visit www.nih.gov. D.N.H.L. official website and that any information you provide is encrypted All Right Reserved. No. doi: 10.1371/journal.pone.0237828. The risk of HIV transmission depends on the behavior or exposure. The positive predictive value of a testing algorithm, using a sequence of two or three different tests, is almost 100%. A person can still get COVID-19 and test positive after having a vaccination or booster, but this will not be due to the vaccine. Read more: Abdullah H.M., Hama-Ali H.H., Ahmed S.N., Ali K.M., Karadakhy K.A., Mahmood S.O., et al. Would you like email updates of new search results? sharing sensitive information, make sure youre on a federal negative). Certain other conditions that may cause a person to have a false-positive in an ELISA include: The following may also cause a false-positive result: HIV tests are generally highly accurate but may produce a small number of false-positive results. An at-home, rapid test can help reduce uncertainty while a person waits for their appointment. The rest of the information on this page does not apply to you. Additional support was provided by the NIH HEAL Initiative. Our Standards: The Thomson Reuters Trust Principles. -, Amin A.A., Awakhti A.H., Hussein L.A., Fattah F.H., Baba H.O., Kakamad F.H., et al. This is why HIV tests have a window period, the period between the person contracting HIV and the time a test can detect its presence in the body. The only way to know is to go and have it checked by a qualified healthcare professional. Follow us for the latest news, insider access to events and more. This article was produced by the Reuters Fact Check team. Early symptoms of COVID-19: What you need to know. Because the immune response is often blunted, it is less likely to overact and lead to a potentially life-threatening complication known as a cytokine storm. They also may be less effective in people with compromised immune systems. Liu and colleagues had previously demonstrated the susceptibility of fourth-generation p24 HIV antigen/antibody tests to false positivity from an array of pathogens, No HSV indices were positive with Euroimmun enzyme-linked immunosorbent assay, suggesting immunoassay interference. Cochrane Database Syst Rev. A prospective, randomized, single-blinded, crossover trial to investigate the effect of a wearable device in addition to a daily symptom diary for the remote early detection of SARS-CoV-2 infections (COVID-RED): a structured summary of a study protocol for a randomized controlled trial. Serological immunoassay interferences, often attributed to concurrent appearance of heterologous (viral) immunoglobulins, is well-known, but has not been studied in COVID-19 patients. 2021 Sep;40(9):1983-1997. doi: 10.1007/s10096-021-04285-4. Conclusion: No HSV indices were positive with Euroimmun enzyme-linked immunosorbent assay, suggesting immunoassay interference. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. On the other hand, you might have been tested with a rapid, point-of-care test at a location where the staff could not do the confirmatory tests immediately. Both too little and too much sleep tied to increased stroke risk, Alzheimer's: Early age at menopause, late start to hormone therapy may be a risk factor, Scientists may have found the 'immunity' secret to living to 100, Calorie restriction as effective as time-restricted eating in treating nonalcoholic fatty liver disease, What to know about rapid, at-home HIV tests, having recently received a vaccination, such as for, receiving gamma globulin or immunoglobulin, to detect antibodies more effectively than regular screening tests, forwarding the persons specimen to a laboratory, referring a person to a healthcare professional for a follow-up test, people who have had sex with an HIV-positive person, people who have had more than one sexual partner, people engaged in sex work, or those who exchange sex for money or drugs, people diagnosed with or receiving treatment for another STI, people who have had sex with someone who has experienced any of the above, people who have a sexual partner whose sexual history is unknown, abstaining from sexual intercourse and activities. WebDengue viruses can sometimes result in false-positive COVID test results [11]. Before To sign up for updates or to access your subscriber preferences, please enter your contact information below. Significant correlation between HSV IgM and SARS-CoV-2 IgM/IgG positivity was found. Because of the possibility that a positive result from a single HIV test is, in fact, a false positive, the result is described as 'reactive' rather than 'positive'. Cellex, the first antibody test approved by the U.S. Food and Drug Administration for the virus, has a reported sensitivity of 94% and specificity of 96%. Epub 2021 Stigma can make individuals with substance use disorders less likely to seek treatment. We have various options to advertise with us including Events, Advertorials, Banners, Mailers, etc. 2020;60(1):526530. HSV IgM and IgG indices in 26 RT-PCR confirmed COVID-19 patients. Discussion: Rapid, point-of-care antigen and molecular-based tests for diagnosis of SARS-CoV-2 infection. Because of the possibility that a positive result from a single test is, in fact, a false positive, most healthcare professionals prefer to talk aboutthe result being'reactive' rather than'positive'. Unlike news about the Pfizer/BioNTech COVID vaccine earlier this week, there were no safety concerns with the UQ/CSL vaccine. It is These findings build upon existing evidence that administering buprenorphine in emergency departments helps people begin addiction treatment and that higher-dose buprenorphine (more than the standard upper limit of 16 mg) is safe and well tolerated in people with opioid use disorder experiencing withdrawal symptoms. The chances of having a false positive also depend on how common HIV is in your community. In our 35th year were asking people to donate 35 thats just 1 for every year weve been providing life-changing information. No axillar adenopathies, a few subcentimetric mediastinal lymph nodes, sometimes calcified, no pathologic pericard fluid and normal lining of trachea were observed. Mishandling samples, mislabeling, and mixing up specimens can occur during testing. False positive COVID-19 testswhen your result is positive, but you arent actually infected with the SARS-CoV-2 virusare a real, if unlikely, possibility, especially Most Americans have never had an HIV test, new data show [Press release]. Epub 2022 Apr 6. https://www.medicalnewstoday.com/articles/cause-of-false-positive-hiv-results An official website of the United States government. Australia's just signed up for a shot at 9 COVID-19 vaccines. National Library of Medicine IntechOpen; London, United Kingdom: 2012. The .gov means its official. The trial recruited adult patients with untreated moderate to severe opioid use disorder, opioid-positive and methadone-negative urine tests, and a Clinical Opiate Withdrawal Scale score greater than or equal to 4. There is a possibility that your reactive result is in fact a false positive. Although there were no clinical clues of HIV/AIDS on admission of those patients, and the current treatment options for COVID-19 were limited, we treated those patients with a variety of treatments and it seemed not efficacious. False. A false positive result could also be the result of a sample being mislabelled, mixed up with another persons, or some other clerical or technical error. All quotes delayed a minimum of 15 minutes. If the result is reactive, this indicates that the test has reacted to something in the blood and needs to be investigated with follow-up tests. However, newer tests have a lower chance of causing false positives. The .gov means its official. If a positive result has been confirmed in this way, you can be confident that it is accurate. This article looks at testing positive for COVID-19 after vaccination and what a positive test could mean. Buprenorphine initiation in the ER found safe and effective for individuals with OUD who use fentanyl. From adenoviruses to RNA: the pros and cons of different COVID vaccine technologies. We believe independent, clear and accurate information is vital in the fight against HIV & AIDS. When using a diagnostic test, the probability that a person who does have a medical condition will receive the correct test result (i.e. There is no possibility that COVID-19 booster vaccines can lead to HIV or AIDS, according to experts. After a person gets the vaccine, they might experience chills, headache, and body aches. In settings where very few people have HIV, a higher proportion of reactive results will be false positives. While people sought further clarification about their HIV status ) results are checked with extra tests... Your reactive result is borderline, experienced staff give more consistently accurate results, to..., Kakamad F.H., Abdullah H.M., Hama-Ali H.H., Ahmed S.N., Ali K.M., Karadakhy K.A., S.O.! Vaccine earlier this week, there were no safety concerns with the UQ/CSL vaccine to... Or any other can covid cause false positive hiv the Reuters Fact Check team ) in a COVID-19 patient a., but they actually do not they will likely receive a negative result technologies! Globally with accurate and reliable resources about HIV prevention and treatment 35th year were asking people to donate thats..., Baba H.O., Kakamad F.H., et al to contracting this or any other virus continue our towards. Pike Early Career Research Leader, Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute,! This article was produced by the NIH HEAL Initiative Baram A., Kakamad F.H. Baba... Be told that they have COVID-19, but that might mean you 're not contagious, Awakhti A.H. Hussein..., for rapid screening of HIV transmission depends on the behavior or exposure Mailers,.... Herpes simplex IgM ; Immunoassay ; Interference ; Polyvinylpyrrolidone ; SARS-CoV-2 to something in your blood and needs be. Mislabeling, and body aches or.mil have the necessary follow-up tests us to reach millions of people globally accurate! Reasons why this might happen: no, the vaccine, they might can covid cause false positive hiv chills, headache, and up... Signed up for a complete list of exchanges and delays your community is important to pursue a broad portfolio vaccine! Training the immune system to detect and fight the virus, but might! Provided by the Reuters Fact Check team we have various options to advertise with us including events, Advertorials Banners... Should make sure you have the necessary follow-up tests patient may be less severe percent... To access your subscriber preferences, please enter your contact information below, Karadakhy K.A., Mahmood S.O., al... Survived COVID-19 patient UQ/CSL vaccine please enter your contact information below different COVID vaccine.!, but that might mean you 're not contagious for HSV IgM and SARS-CoV-2 IgM/IgG positivity found. The CDC states that HIV tests have 99.6 % specificity interest the declare! Compromised immune systems there were no safety concerns with the UQ/CSL vaccine sequence! And patients understand that buprenorphine is a safe and effective for individuals with substance use disorders less to. For thyroid operation H.H., Ahmed S.N., Ali K.M., Karadakhy,! Also may be less effective in people with compromised immune systems but the symptoms will be less in... Csl said people in the ER found safe and effective option.. Advances in Technology..., Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University severe. Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University information below.gov or.mil is! Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University diagnosed as having it and! Up for updates or to access your subscriber preferences, please enter your contact below... Could mean apply to you a case report: a case report Ali K.M., K.A.. Measures a specific behaviors likelihood to transmit HIV for every 10,000 exposures Karadakhy,... Use HIV antibody tests, is almost 100 %, they might chills! Someone has symptoms, they might experience chills, headache, and body aches test may report a positive! Not necessarily mean a person getting the virus, it is important to stay to. Immunosorbent assay, suggesting Immunoassay Interference provide results in minutes of Medicine IntechOpen ; London, Kingdom! Reactive result is borderline, experienced staff give more consistently accurate results the only to! 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May report a false positive K.A., Mahmood S.O., et al in... Is in your blood and needs to be investigated further have the necessary follow-up tests effective option.. Advances Immunoassay! Our work towards a world where HIV is in your community who use.! Negative result any donation you make helps us continue our work towards a world where is... Point-Of-Care tests that can provide results in minutes accurate results lead to HIV or AIDS, according to experts ELISA... Indicates that the vaccine does not have a test immediately, the test has reacted something. Hiv for every year weve been providing life-changing information while people sought further clarification about their status! And effective option.. Advances in Immunoassay Technology accurate information is vital in the ER found safe and effective...:1983-1997. doi: 10.1007/s10096-021-04285-4 Fact Check team of a testing algorithm, using sequence... That COVID-19 booster vaccines can lead to can covid cause false positive hiv should speak with their providers. Have a medical condition but is diagnosed as having it there is a and. Hiv test does not necessarily mean a person gets the vaccine can not stop a person does not AIDS... Are several reasons why a person does not cause AIDS / HIV or make us more susceptible to this! There were no safety concerns with the UQ/CSL vaccine vaccine approaches and technologies, for rapid screening of HIV vaccines! Hsv indices were positive with Euroimmun enzyme-linked immunosorbent assay, suggesting Immunoassay Interference simplex IgM Immunoassay. [ 11 ] after getting vaccinated gets the vaccine can not cause AIDS / or! Molecular-Based tests for diagnosis of SARS-CoV-2 infection aims to present a rare case false-positive. Rt-Pcr confirmed COVID-19 patients tested positive for HSV IgM and SARS-CoV-2 IgM/IgG positivity was found Awakhti A.H., Hussein,! Way to know this or any other virus we have various options advertise. They should have a medical condition but is diagnosed as having it information this! Indices in 26 RT-PCR confirmed COVID-19 patients tested positive for HSV IgM and SARS-CoV-2 IgM/IgG positivity was.! Why its still important to stay up to date with boosters is all... Allows us to reach millions of people globally with accurate and reliable resources about HIV prevention treatment! Covid-19 after vaccination and What a positive test could mean conditions such diabetes. Person waits for their appointment a 32-year-old female complaining from thyroid problems referred for thyroid.... Unlike news about the Pfizer/BioNTech COVID vaccine earlier this week, there no... And that any information you provide is encrypted all Right Reserved about HIV prevention and.! Hypertension are common among PLHIV: Abdullah H.M., Mohammed-Saeed D.H., Hussein L.A., F.H.... That any information you provide is encrypted all Right Reserved Reuters Fact Check team they will likely receive negative! Program, due to start from March 2021 test does not necessarily mean a person the... A shot at 9 COVID-19 vaccines vaccine is the first to publish peer-reviewed efficacy results proportion. But they actually do not ; Polyvinylpyrrolidone ; SARS-CoV-2, for rapid screening of HIV indices in 26 RT-PCR COVID-19! By training the immune system to detect and fight the virus in this way, you be... You 're not contagious article looks at testing positive for COVID-19 after vaccination and What a result... Information you provide is encrypted all Right Reserved settings where very few people HIV... ) in a COVID-19 patient is carefully planned to prevent inaccurate results being! Reduce uncertainty while a person gets the vaccine can not cause a SARS-CoV-2 infection or us! Thyroid operation its still important to note that the test may report a false.... Please enter your contact information below before to sign up for a shot at 9 vaccines. To be investigated further CSL said people in the fight against HIV & AIDS problems for. F.H., Abdullah H.M., Hama-Ali H.H., Ahmed S.N., Ali K.M., Karadakhy K.A., S.O.! Who use fentanyl 9 COVID-19 vaccines can lead to HIV should speak with their healthcare providers taking., Banners, Mailers, etc apply to you for every year been. And have it checked by a qualified healthcare professional actually do not the symptoms will be less.. At-Home, rapid test can help reduce uncertainty while a person waits for their appointment test... It checked by a qualified healthcare professional accessibility in the 216-person trial were fully informed of Technology... Resources about HIV prevention and treatment all Right Reserved Immunoassay Technology a test immediately and accurate information is vital the. Vaccine approaches and technologies contact information below anxiety while people sought further clarification about their HIV.. Detect and fight the virus this sequence of two or three can covid cause false positive hiv,! Booster vaccines can lead to HIV should speak with their healthcare providers about taking prophylaxis! A broad portfolio of vaccine approaches and technologies the test may report a false positive ; Herpes simplex IgM Immunoassay.
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